报告题目：Large-scale Brain Dynamical Mechanisms for Absence Seizures

报告人：杨冬平研究员

时  间：2021/5/26 14:30-15:30（周三）

地  点：腾讯会议   会议ID：542 754 914   密码:123456

会议直播:：https://meeting.tencent.com/s/PoY1JTC08veZ

报告人简介：杨冬平博士2011年毕业于厦门大学物理系，获得凝聚态物理理学博士学位；随后在香港浸会大学物理系，澳大利亚悉尼大学物理系从事计算神经科学和脑物理的基础理论研究。杨冬平博士2020年入选福建省引进高层次人才，现任中国科学院海西研究院泉州装备制造研究所研究员，并组建“脑物理与神经计算”课题组，长期关注大脑活动的生物物理动力学机制，特别是与睡眠调控和癫痫产生相关的动力学机制。

报告摘要：Absence epilepsy is characterized by a sudden paroxysmal loss of consciousness accompanied by oscillatory activity propagating over many brain areas. A physiologically based corticothalamic model of large-scale brain activity is used to analyze critical dynamics of transitions from normal arousal states to epileptic seizures, which correspond to Hopf bifurcations. This relates an abstract normal form quantitatively to the main underlying physiologies that includes neural dynamics, axonal propagation, and time delays. Thus, a bridge is constructed that enables normal forms to be used to interpret quantitative data. This model is further investigated with focal spatial heterogeneity, numerically and analytically. An emergent spatiotemporal dynamic is found for seizure localization, whose spatiotemporal properties are comparable with experimental observations, providing a new biophysical explanation of the temporally higher frequency, but spatially more localized cortical waves observed in genetic rodents that display characteristics of human absence epilepsy, from the perspective of large-scale brain dynamics. Predictions are also presented for further experimental test. Thus, we propose a dynamical mechanism to unify the global and focal aspects of absence epilepsy with focal absence seizures associated with localized seizures, and the global ones associated with generalized seizures. More details of cellular nonlinear dynamics or heterogeneous connectivity can be further introduced into the large-scale Physical brain system for future studies.